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Many patients find that tapentadol is one of the most effective pain relievers, while other individuals depend on it for back pain, chronic pain, and short-term pain relief. When it comes to 100 mg formulations, it is the most popular pain reliever. After being approved and becoming the best-selling medication in the US for the treatment of moderate chronic pain, it was also approved in Australia. When tapentadol is taken orally, conventional formulations cause the medication to release quickly.